Stochastic modeling of epigenetic memory
Abstract
Here, we review mathematical models of epigenetic memory, focusing on chromatin modifications as key mechanisms to achieve long-term maintenance of epigenetic states. After reviewing the main stochastic modeling frameworks, we focus on stochastic models of chromatin modifications to analyze residence time in memory states, which underpins the long-term maintenance of epigenetic information. We review these concepts through increasingly complicated chromatin modification circuits, including histone modifications, DNA methylation, and their combination.
Fields of Study & Subjects
Gene Regulatory Network Analysis
Epigenetics and DNA Methylation
Genomics and Chromatin Dynamics
Publication details
- Journal / source
- npj Systems Biology and Applications
- Volume
- 12
- Issue
- 1
- Publication date
- 11 March 2026
- Language
- EN