Matters of life and death in computational cell biology

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Authors: Connor McShaffrey, Eran Agmon, Randall D. Beer
Cited by: 1
References: 87

Abstract

Many cell models deal with constraints for life's persistence, yet we lack principles for how dynamics interact with them and their origins in actual biology. Computational biology needs a theory of viability that confronts the life-death boundary to overcome this. We explore how geometric structures in a model's state space offer organizing principles for cell fate, and how idealized models of emergent individuals may help explain life's intrinsically generated limits.

Fields of Study & Subjects

Gene Regulatory Network Analysis Planarian Biology and Electrostimulation Plant and Biological Electrophysiology Studies

Publication details

Journal / source
npj Systems Biology and Applications
Publisher
Springer Science and Business Media LLC
Volume
12
Issue
1
Publication date
20 April 2026
Language
EN