From promise to pitfalls: immunological lessons from dengue vaccines and their implications
Abstract
Dengue continues to pose a significant global health threat. However, the development of a safe and effective tetravalent vaccine is impeded by complex serotype-specific and cross-reactive immune responses. This review assesses licensed and advanced dengue vaccines, emphasizing serostatus-dependent safety, serotype imbalance, and the durability of protection. It also critically evaluates immunological correlates of protection and addresses remaining obstacles, such as vector-mediated immune modulation and orthoflavivirus cross-reactivity, to guide future dengue vaccine strategies.
Fields of Study & Subjects
Mosquito-borne diseases and control
Viral Infections and Outbreaks Research
Parasitic Diseases Research and Treatment
Publication details
- Journal / source
- npj Vaccines
- Publisher
- Springer Science and Business Media LLC
- Volume
- 11
- Issue
- 1
- Publication date
- 14 February 2026
- Language
- EN