Gonococcal outer membrane vesicle vaccines: bacterial population biology, clinical trials, immune profiling, and vaccine design

npj Vaccines 2026 Open access

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Authors: ZhenYi Gu, Anastasia Unitt, Odile B. Harrison, Jeremy P. Derrick, Ann E. Jerse, Samantha A McKeand, Christoph M. Tang
DOI: 10.1038/s41541-026-01410-2
Cited by: 2
References: 84

Abstract

Gonorrhoea is a global health concern exacerbated by rising antimicrobial resistance. Retrospective analyses indicate that outer membrane vesicle (OMV) vaccines derived from Neisseria meningitidis (MeNZB, 4CMenB) may offer partial cross-protection against gonococcal infection. This review outlines the influence of gonococcal population biology on coverage, immune responses elicited by 4CMenB, and emerging strategies that offer the prospect of rationally designed vaccines dedicated to the prevention of gonococcal disease.

Fields of Study & Subjects

Bacterial Infections and Vaccines Reproductive tract infections research Immune responses and vaccinations

Publication details

Journal / source
npj Vaccines
Publisher
Springer Science and Business Media LLC
Volume
11
Issue
1
Publication date
5 March 2026
Language
EN