The current landscape of therapeutic vaccination approaches for treatment of HPV-dependent malignancies

npj Vaccines 2026 Open access

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Authors: Johanne Audouze-Chaud, Axel Schlösser, Angelika B. Riemer
DOI: 10.1038/s41541-026-01426-8
Cited by: 3
References: 129

Abstract

This review provides an overview of current therapeutic human papillomavirus (HPV) vaccination approaches. We review important criteria for their development, and present vaccines currently being actively followed in clinical trials, for precursor lesions or established cancers. Subsequently, we list approaches that reached clinical trial stage but were abandoned. Lastly, we discuss promising preclinical studies. We conclude with a brief overview of novel in silico tools developed to enhance vaccine design.

Fields of Study & Subjects

Cervical Cancer and HPV Research Immunotherapy and Immune Responses vaccines and immunoinformatics approaches

Publication details

Journal / source
npj Vaccines
Publisher
Springer Science and Business Media LLC
Volume
11
Issue
1
Publication date
15 April 2026
Language
EN