BCG enables protection against malaria through adjuvanting an adenovirus-vectored vaccine

npj Vaccines 2026 Open access

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Authors: Sören Reinke, Marta Ulaszewska, Qi Su, Lee Sims, Romain Guyon, Adam Truby, Gundra Raissar, Jelena S. Bezbradica, Joannah R. Fergusson, Anita Milicic
DOI: 10.1038/s41541-026-01506-9
Cited by: 0
References: 29

Abstract

Abstract BCG vaccination against TB may also reduce malaria incidence through non-specific innate immune activation. We investigated whether giving BCG alongside an adenoviral-vectored malaria vaccine improves protection against malaria in mice. Co-immunisation broadened and strengthened the early innate cytokine responses, enabling strong CD8 + T cell-dependent protection. Our findings suggest co-immunisation with BCG and adenoviral vector as a promising strategy to combat both TB and malaria in double-endemic regions.

Fields of Study & Subjects

Immune responses and vaccinations Viral Infections and Outbreaks Research Zoonotic diseases and public health

Publication details

Journal / source
npj Vaccines
Publisher
Springer Science and Business Media LLC
Volume
11
Issue
1
Publication date
24 June 2026
Language
EN