Single-nucleus transcriptomics of an engineered pig model reveals microglia–T cell interactions driving Huntington’s disease neurodegeneration

Nature Biomedical Engineering 2026

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Authors: Jiawei Li, Yingqi Lin, Jiale Gao, Fan Yang, Caijuan Li, Yizhi Chen, Chunhui Huang, Xichen Song, Zebu Song, Jianhao Wu, Jiaxi Wu, Wei Wang
+10 more Junzhu Song, Chunxiang Shi, Guangchao Cao, Yan Xu, Yankuo Sun, Zhuchi Tu, Liangxue Lai, S. Li, Xiao‐Jiang Li, Sen Yan
DOI: 10.1038/s41551-026-01621-x
Cited by: 2
References: 104

Fields of Study & Subjects

Genetic Neurodegenerative Diseases Amyotrophic Lateral Sclerosis Research Neuroinflammation and Neurodegeneration Mechanisms

Publication details

Journal / source
Nature Biomedical Engineering
Publisher
Springer Science and Business Media LLC
Publication date
24 February 2026
Language
EN