Formal Diels–Alder reaction of saturated carboxylic acids via C–H activation

Nature Chemistry 2026 Open access

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Authors: Qiyuan He, Yilin Lu, Tao Sheng, Nikita Chekshin, Jie-Lun Yan, Tao Zhang, J.-Q. Yu
DOI: 10.1038/s41557-026-02077-x
Cited by: 5
References: 20

Abstract

Bridged bicyclic frameworks are valuable in medicinal chemistry but difficult to access from simple saturated precursors. In situ generation of cyclic 1,3-dienes from unactivated carboxylic acids remains challenging. Now it has been shown that ligand-guided Pd(II) C–H activation enables multi-step diene formation for highly selective formal Diels–Alder reactions.

Fields of Study & Subjects

Catalytic C–H Functionalization Methods Cyclopropane Reaction Mechanisms Catalytic Cross-Coupling Reactions

Publication details

Journal / source
Nature Chemistry
Publisher
Springer Science and Business Media LLC
Volume
18
Issue
5
Pages
893–898
Publication date
20 February 2026
Language
EN