A disease-severity-responsive nanoparticle enables potent ghrelin messenger RNA therapy in osteoarthritis

Nature Nanotechnology 2026 Open access

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Authors: Mahima Dewani, Anjali Rajesh Mamidwar, Miraj Rawal, Bhingaradiya Nutan, Jingshu Liu, Nishkal D. Pisal, Sihan Liu, Elyse Blank, Arpita Banerjee, Dongsung Park, Christopher Jiang, Aashman Gupta
+10 more Shrihari D. Katti, Keren Chen, Ziting Xia, Amirtaa Nedumaran, Joshua Karp, Sohyung Lee, Jeffrey M. Karp, Jingjing Gao, Nitin Joshi, Li Zeng
DOI: 10.1038/s41565-025-02101-0
Cited by: 8
References: 63

Fields of Study & Subjects

Osteoarthritis Treatment and Mechanisms RNA Interference and Gene Delivery Regulation of Appetite and Obesity

Publication details

Journal / source
Nature Nanotechnology
Publisher
Springer Science and Business Media LLC
Volume
21
Issue
3
Pages
455–466
Publication date
14 January 2026
Language
EN