Engineered mucus-tethering bispecific nanobodies enhance mucosal immunity against respiratory pathogens

Nature Nanotechnology 2026

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Authors: L. Zhao, Kyle L. O’Donnell, Megha Dubey, Yuting Wang, Nathan R. Martinez, Yunxiao Zhang, Holly Steininger, Chao Ma, Vamsee Mallajosyula, Lorene L.Y. Lee, Rovin Lachmansingh, Suzan P. Stavitsky
+25 more Eri Takematsu, Malachia Hoover, Honglin Chen, Jing Guo, Annette Wu, Yifan Ma, Xiaotian Wang, Ansel P. Nalin, Seong Dong Jeong, Wan-Jin Lu, P. H. Nguyen, Chad S. Clancy, Michal C. Tal, Jun Xiao, Michael T. Longaker, Andrew S. Lee, Betty Y.S. Kim, Thomas H. Ambrosi, Weissman Il, Mark M. Davis, Kim J. Hasenkrug, Yueh‐hsiu Chien, W. Jiang, Marzi Andrea, Charles K. F. Chan
DOI: 10.1038/s41565-025-02107-8
Cited by: 2
References: 49

Fields of Study & Subjects

Monoclonal and Polyclonal Antibodies Research vaccines and immunoinformatics approaches Biochemical and Structural Characterization

Publication details

Journal / source
Nature Nanotechnology
Publisher
Springer Science and Business Media LLC
Volume
21
Issue
3
Pages
419–429
Publication date
21 January 2026
Language
EN