Synthesizing scientific literature with retrieval-augmented language models

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Authors: Akari Asai, Jacqueline He, Rulin Shao, Weijia Shi, Amanpreet Singh, Joseph Chee Chang, Kyle Shih-Huang Lo, Luca Soldaini, Sergey Feldman, Mike D’Arcy, David Wadden, Matt Latzke
+16 more Jenna Sparks, Jena D. Hwang, Varsha Kishore, Minyang Tian, Pan Ji, Shengyan Liu, Hao Tong, Bohao Wu, Yanyu Xiong, Luke Zettlemoyer, Graham Neubig, Daniel S. Weld, Doug Downey, Wen-tau Yih, Pang Wei Koh, Hannaneh Hajishirzi
Cited by: 28
References: 44

Abstract

Scientific progress depends on the ability of researchers to synthesize the growing body of literature. Can large language models (LLMs) assist scientists in this task? Here we introduce OpenScholar, a specialized retrieval-augmented language model (LM)1 that answers scientific queries by identifying relevant passages from 45 million open-access papers and synthesizing citation-backed responses. To evaluate OpenScholar, we develop ScholarQABench, the first large-scale multi-domain benchmark for literature search, comprising 2,967 expert-written queries and 208 long-form answers across computer science, physics, neuroscience and biomedicine. Despite being a smaller open model, OpenScholar-8B outperforms GPT-4o by 6.1% and PaperQA2 by 5.5% in correctness on a challenging multi-paper synthesis task from the new ScholarQABench. Although GPT-4o hallucinates citations 78–90% of the time, OpenScholar achieves citation accuracy on par with human experts. OpenScholar’s data store, retriever and self-feedback inference loop improve off-the-shelf LMs: for instance, OpenScholar-GPT-4o improves the correctness of GPT-4o by 12%. In human evaluations, experts preferred OpenScholar-8B and OpenScholar-GPT-4o responses over expert-written ones 51% and 70% of the time, respectively, compared with 32% for GPT-4o. We open-source all artefacts, including our code, models, data store, datasets and a public demo. A specialized, open-source, retrieval-augmented language model is introduced for answering scientific queries and synthesizing literature, the responses of which are shown to be preferred by human evaluations over expert-written answers.

Fields of Study & Subjects

Artificial Intelligence in Healthcare and Education Biomedical Text Mining and Ontologies Topic Modeling

Publication details

Journal / source
Nature
Publisher
Springer Science and Business Media LLC
Volume
650
Issue
8103
Pages
857–863
Publication date
4 February 2026
Language
EN