Spermine is an endogenous iron chelator that inhibits ferroptosis

Nature 2026

View at publisher
Authors: Man Li, Xuexin Yu, Shuqin Ouyang, Xiaohong Chen, Huiqi Yu, Yuanji Liu, Ziwen Li, Chunhua Yu, Rui Kang, Christine Gaillet, Ludovic Colombeau, Raphaël Rodriguez
+4 more Libing Song, Guido Kroemer, Daolin Tang, Jun Li
DOI: 10.1038/s41586-026-10597-2
Cited by: 8
References: 60

Fields of Study & Subjects

Ferroptosis and cancer prognosis Iron Metabolism and Disorders Trace Elements in Health

Publication details

Journal / source
Nature
Publisher
Springer Science and Business Media LLC
Volume
655
Issue
8121
Pages
240–250
Publication date
3 June 2026
Language
EN