De novo design of miniproteins targeting GPCRs

Nature 2026

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Authors: Edin Muratspahić, David Feldman, D K Kim, Xiangli Qu, Ana-Maria Bratovianu, Paula Rivera-Sánchez, Jan Voss, Emil P. T. Hertz, Mads Jeppesen, Federica Dimitri, Kensuke Sakamoto, Amrita Nallathambi
+60 more Pia Peceli, Jianjun Cao, Brian P. Cary, Matthew J. Belousoff, Peter Keov, Phuc N. H. Trinh, Qingchao Chen, Yue Ren, Justyn Fine, Sudha Mishra, Annu Dalal, Shachie Sinha, Ramanuj Banerjee, Manisankar Ganguly, Karthik Varappalayam Karuppusamy, Isaac Sappington, Thomas Schlichthaerle, Jason Z. Zhang, Arvind Pillai, Brian Coventry, Ljubica Mihaljević, Magnus Bauer, Susana Vázquez Torres, Amir Motmaen, Gyu Rie Lee, Long Tran, Xinru Wang, Inna Goreshnik, Dionne Vafeados, Justin E. Svendsen, Parisa Hosseinzadeh, Nicolai Lindegaard, Matthäus Brandt, Yann Waltenspühl, Kristine Deibler, Lukas Deweid, Anja Bennett, Jendrik Schöppe, Tiantang Dong, Xiaoli Yan, Luke Oostdyk, William Cao, Lakshmi Anantharaman, Johan J. Weisser, Jesper F. Bastlund, Christoffer Bundgaard, Ayodeji A. Asuni, Justin G. English, Lance Stewart, Lauren Halloran, Jamie B. Spangler, André Lieber, Arun K. Shukla, Patrick M. Sexton, Bryan L. Roth, B. Krumm, Denise Wootten, Christopher G. Tate, Christoffer Norn, David Baker
DOI: 10.1038/s41586-026-10656-8
Cited by: 7
References: 77

Fields of Study & Subjects

Receptor Mechanisms and Signaling Monoclonal and Polyclonal Antibodies Research Biochemical and Structural Characterization

Publication details

Journal / source
Nature
Publisher
Springer Science and Business Media LLC
Volume
656
Issue
8129
Pages
1044–1053
Publication date
21 May 2026
Language
EN