Customizing CRISPR–Cas PAM specificity with protein language models

Nature Biotechnology 2026

View at publisher
Authors: Stephen Nayfach, Aadyot Bhatnagar, Andrey Novichkov, Nahye Kim, Alexander M. Hoffnagle, Riffat Hussain, Gabriella O. Estevam, Emily Hill, Jeffrey A. Ruffolo, Rachel A. Silverstein, Joseph Gallagher, Benjamin P. Kleinstiver
+3 more Alexander J. Meeske, Peter Cameron, Ali Madani
DOI: 10.1038/s41587-025-02995-0
Cited by: 11
References: 71

Fields of Study & Subjects

CRISPR and Genetic Engineering Genomics and Rare Diseases Machine Learning in Bioinformatics

Publication details

Journal / source
Nature Biotechnology
Publisher
Springer Science and Business Media LLC
Publication date
2 February 2026
Language
EN