Dynamic transitioning between MAPK-driven and WNT-driven cell states drives intestinal cancer and shapes therapy response

Nature Genetics 2026

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Authors: Amanda R. Moore, Brian Biehs, Noelyn Kljavin, Thi Thu Thao Nguyen, Akansha M. Shah, Jeremy Burton, Honglin Jiang, Jenille Tan, Deepankar Chakroborty, Lisa Wang, Nayan Chaudhary, Dongze He
+11 more William Lin, Kathryn Mesh, Xin Ye, Kamakoti P. Bhat, Lisa Tai, Shiqi Xie, Weilan Ye, Lisa McGinnis, Shiva Malek, Sandra P. Melo, Frédéric J. de Sauvage
DOI: 10.1038/s41588-026-02611-0
Cited by: 3
References: 86

Fields of Study & Subjects

Cancer Cells and Metastasis Wnt/β-catenin signaling in development and cancer Liver physiology and pathology

Publication details

Journal / source
Nature Genetics
Publisher
Springer Science and Business Media LLC
Volume
58
Issue
6
Pages
1331–1340
Publication date
1 June 2026
Language
EN