GCN5–ERK lactylation–phosphorylation loop amplifies lactate-driven cancer progression

Nature Chemical Biology 2026

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Authors: Bingsong Huang, Mingpeng Jin, Gaofeng Cui, Zhe WANG, Feng Wang, Mu Chen, Lei Zhu, Yunxuan Li, Xiaoning Yang, Rui Li, Jinhuan Wu, Linhui Zhai
+15 more Yiming He, Jie Yang, Xin Ding, Qianwen Wang, Zhen Xv, Yaobing Ouyang, Jiale Li, Yangbohui Yang, Ke Li, Zhenkun Lou, Georges Mer, Jing Zhang, Yuping Chen, Jian Yuan, Chunlong Zhong
DOI: 10.1038/s41589-025-02107-8
Cited by: 20
References: 67

Fields of Study & Subjects

Cancer Hypoxia and Metabolism Proteoglycans and glycosaminoglycans research Melanoma and MAPK Pathways

Publication details

Journal / source
Nature Chemical Biology
Publisher
Springer Science and Business Media LLC
Volume
22
Issue
4
Pages
634–648
Publication date
13 January 2026
Language
EN