A druggable redox switch on SHP1 controls macrophage inflammation

Nature Chemical Biology 2026 Open access

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Authors: Mei Ying Ng, Meredith Nicole Nix, Guangyan Du, Ivan Davidek, Nils Burger, Sanghee Shin, Sean T. Toenjes, Haruna Takeda, Megan Cheah Xin Yan, Bingsen Zhang, Haopeng Xiao, Shelley M Wei
+9 more Hyuk‐Soo Seo, Sirano Dhe-Paganon, Thomas E. Wales, John Engen, Evanna L. Mills, Jianwei Che, Tinghu Zhang, Nathanael S. Gray, Edward T. Chouchani
DOI: 10.1038/s41589-026-02163-8
Cited by: 2
References: 74

Fields of Study & Subjects

Redox biology and oxidative stress Sulfur Compounds in Biology Neutrophil Myeloperoxidase and Oxidative Mechanisms

Publication details

Journal / source
Nature Chemical Biology
Publisher
Springer Science and Business Media LLC
Volume
22
Issue
7
Pages
1187–1200
Publication date
12 March 2026
Language
EN