The molecular glue CLEO4-88 inhibits the ACAA1 thiolase by induced binding to GID4

Nature Chemical Biology 2026

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Authors: Chetan K. Chana, Ines Ben Makhlouf, Jaeyoun Kim, Annie Yu, Nathalie Moatti, Stephen Orlicky, Cassandra Wong, Leon H Baronijan, XiaoJing Tang, Daniel Y.L. Mao, Brett Larsen, Laura McGary
+9 more Brendon Seale, P. Mäder, Derek F. Ceccarelli, Philip Barbulescu, Rossanna C. Pezo, Daniel Durocher, Laurence Pelletier, Anne-Claude Gingras, Frank Sicheri
DOI: 10.1038/s41589-026-02183-4
Cited by: 2
References: 36

Fields of Study & Subjects

Protein Degradation and Inhibitors Click Chemistry and Applications Ubiquitin and proteasome pathways

Publication details

Journal / source
Nature Chemical Biology
Publisher
Springer Science and Business Media LLC
Volume
22
Issue
10
Pages
1589-1598
Publication date
9 April 2026
Language
EN