Development of a clinically viable MRGPRX4 inverse agonist for cholestatic itch treatment

Nature Chemical Biology 2026

View at publisher
Authors: Jun Yang, Ruichao Shen, Chunyu Wang, Wenneng Zhu, Han Ke, Junping Fan, Mengna Zhang, Yingjun Liu, Shuai Li, Guochuan Li, Xiaoming Wang, Yulong Li
+2 more Can Cao, Xiaoguang Lei
DOI: 10.1038/s41589-026-02195-0
Cited by: 3
References: 47

Fields of Study & Subjects

Dermatology and Skin Diseases Drug Transport and Resistance Mechanisms Mast cells and histamine

Publication details

Journal / source
Nature Chemical Biology
Publisher
Springer Science and Business Media LLC
Volume
22
Issue
10
Pages
1599-1609
Publication date
9 April 2026
Language
EN