Active aldehydes accelerate CD8+ T cell exhaustion by metabolic alteration in the tumor microenvironment

Nature Immunology 2026

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Authors: Yasuharu Haku, Koji Kitaoka, Koki Ichimaru, T Hirano, Jun Wang, Kazuhiro Sonomura, Asuka Maruo, Shuhei Hirose, Yanru Wang, Katsuhiro Ito, Tomohiro Kozuki, Keiko Yurimoto
+9 more Mai Kiyono, Hidetaka Kosako, T. Menju, Hiroshi Date, Takashi Kobayashi, Koichi Omori, Tomonori Yaguchi, Tasuku Honjo, Kenji Chamoto
DOI: 10.1038/s41590-025-02370-w
Cited by: 16
References: 76

Fields of Study & Subjects

Antioxidant Activity and Oxidative Stress Cancer Immunotherapy and Biomarkers Alcohol Consumption and Health Effects

Publication details

Journal / source
Nature Immunology
Publisher
Springer Science and Business Media LLC
Volume
27
Issue
2
Pages
281–294
Publication date
7 January 2026
Language
EN