Single-cell multiomic atlas of healthy pediatric bone marrow reveals age-dependent differences in lineage differentiation driven by stromal signaling

Nature Immunology 2026 Open access

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Authors: Evelyn S. Hanemaaijer, Konradin F. Müskens, Ireen J. Kal, Li‐Ting Chen, Brigit M. te Pas, Patrycja Fryzik, Nina Epskamp, Merel van der Meulen, Aleksandra Balwierz, Akshaya K. Saikumar Jayalatha, Marijn Scheijde-Vermeulen, Olaf Heidenreich
+4 more Tito Candelli, Wim J. de Jonge, T Margaritis, Mirjam E. Belderbos
DOI: 10.1038/s41590-026-02422-9
Cited by: 3
References: 60

Abstract

Childhood is a critical period for hematopoietic development and susceptibility to hematologic disease. Here we generated a multimodal single-cell atlas of healthy human bone marrow, capturing mRNA and surface protein expression in 90,710 cells, including over 20,000 hematopoietic stem and progenitor cells (HSPC) and mesenchymal stromal cells (MSC) from nine donors ranging from infancy to young adulthood (2–32 years). Young pediatric (YP) bone marrow (

Fields of Study & Subjects

Hematopoietic Stem Cell Transplantation Single-cell and spatial transcriptomics Acute Myeloid Leukemia Research

Publication details

Journal / source
Nature Immunology
Publisher
Springer Science and Business Media LLC
Volume
27
Issue
3
Pages
613–623
Publication date
17 February 2026
Language
EN