The TREM2 agonistic antibody AL002 in early Alzheimer’s disease: a phase 2 randomized trial

Nature Medicine 2026

View at publisher
Authors: Catherine J. Mummery, Arthur J. Mayorga, Adam Simmons, T.W. Chow, Brady Burgess, Tuan Nguyen, Jingjing Gao, Balasubrahmanyam Budda, Lovingly Quitania Park, Ruchi Gupta, Caiyan Li, Li Shi
+9 more Sara Kenkare-Mitra, Arnon Rosenthal, Robert Paul, Michael P. Ward, Derk D. Purcell, Stephen Salloway, Michael Grundman, Gary Romano, Giacomo Salvadore
DOI: 10.1038/s41591-026-04273-1
Cited by: 18
References: 51

Fields of Study & Subjects

Neuroinflammation and Neurodegeneration Mechanisms Neurological Disease Mechanisms and Treatments Inflammation biomarkers and pathways

Publication details

Journal / source
Nature Medicine
Publisher
Springer Science and Business Media LLC
Volume
32
Issue
5
Pages
1708–1716
Publication date
5 March 2026
Language
EN