Trabectedin and low-dose irinotecan to target EWS::FLI1 in Ewing sarcoma: a phase 1/2 trial

Nature Medicine 2026

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Authors: Patrick Joseph Grohar, Rachel S. Heise, Mary Frances Wedekind, Karla V. Ballman, Leo Mascarenhas, Steven G. DuBois, Robert G. Maki, Elissa A. Boguslawski, Jenna Marie Gedminas, Elizabeth R. Wilson, E. Donnall Thomas, Blair Segers
+24 more Lea F. Surrey, Cora A. Ricker, Kelly S. Klega, Fariba Navid, Gretchen Y. Lam, Stephanie The, R.L. Kaufman, Ryan D. Roberts, Masanori Hayashi, Esther Mena, Lindsey Overman, Cody Peer, Keith Schmidt, Mark S. Diamond, William D. Figg, Rochelle Bagatell, M. Liza Lindenberg, Peter L. Choyke, Brian D. Crompton, Brigitte C. Widemann, John W. Glod, Theodore Willis Laetsch, Denise K. Reinke, Rashmi K Chugh
DOI: 10.1038/s41591-026-04340-7
Cited by: 1
References: 53

Fields of Study & Subjects

Sarcoma Diagnosis and Treatment Acute Myeloid Leukemia Research Lung Cancer Treatments and Mutations

Publication details

Journal / source
Nature Medicine
Publisher
Springer Science and Business Media LLC
Volume
32
Issue
6
Pages
2227–2237
Publication date
16 April 2026
Language
EN