Oral KRAS G12D inhibitor GFH375 for previously treated advanced solid tumors with KRASG12D mutations: a phase 1 trial

Nature Medicine 2026

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Authors: Xinghao Ai, Zhengbo Song, Lin Wu, Aiping Zhou, Di Cheng, Hong Zong, Heshui Wu, 牛作兴, Yuping Sun, Lingjun Zhu, Zhiwei Li, Yanhong Deng
+13 more Ying Shu Yuan, Xiujuan Qu, Haitao Zhao, Yingying Du, Ziming Li, Yu Wang, Haige Shen, Huaqiang Zhu, Chanli Zheng, Shuang Wang, Zhao Cui, Lingyu Tai, Shun Lü
DOI: 10.1038/s41591-026-04559-4
Cited by: 1
References: 53

Fields of Study & Subjects

Protein Kinase Regulation and GTPase Signaling HER2/EGFR in Cancer Research Colorectal Cancer Treatments and Studies

Publication details

Journal / source
Nature Medicine
Publisher
Springer Science and Business Media LLC
Volume
32
Issue
9
Pages
3302–3312
Publication date
1 September 2026
Language
EN