Exploring the chemodiversity of antimicrobial minalemines from Didemnum granulatum by neutral loss graph

Scientific Reports 2026 Open access

Read full text
Authors: Vítor F. Freire, Jason R. Evans, Lucero Martínez-Fructuoso, Rohitesh Kumar, Rhone K. Akee, Svetlana Hogan, Christopher C. Thornburg, Brian D. Peyser, Susan M. Ensel, Dong Wang, Tanja Grkovic, Barry R. O’Keefe
DOI: 10.1038/s41598-025-32070-2
Cited by: 0
References: 37

Abstract

In this study, we report on the identification of the active antimicrobial principles from the tunicate Didemnum granulatum. Two new natural products, minalemines G (1) and H (2), were isolated and their structures were elucidated. Both compounds showed potent antibacterial activity, with compound 1 showing sub-microgram inhibition against Staphylococcus aureus. Moreover, we also report a new mass spectrometry-based approach, named neutral loss graph, developed to explore minor metabolites from complex mixtures. This approach was applied here to reveal twelve additional minalemine analogues in the organic extract of D. granulatum.

Fields of Study & Subjects

Marine Sponges and Natural Products Advanced Synthetic Organic Chemistry Chemical synthesis and alkaloids

Publication details

Journal / source
Scientific Reports
Volume
16
Issue
1
Pages
2311–2311
Publication date
7 January 2026
Language
EN