Spontaneous somatic Pten loss contributes to functional heterogeneity of T cells
Abstract
We found that healthy mice harbor T cells with heritable low Pten expression and that monoallelic Pten loss in CD4 T cells causes a bias in their differentiation toward T follicular helper cells during acute viral infection. These results suggest that somatically induced mono- or biallelic loss of expression of signaling-related genes in T cells can impact the quality of population-level T cell responses-without conspicuous pathological sequelae such as autoimmune and inflammatory manifestations or lymphomagenesis.
Fields of Study & Subjects
T-cell and B-cell Immunology
Psoriasis: Treatment and Pathogenesis
Developmental Biology and Gene Regulation
Publication details
- Journal / source
- Scientific Reports
- Volume
- 16
- Issue
- 1
- Pages
- 5071–5071
- Publication date
- 12 January 2026
- Language
- EN