Retraction Note: BRCA1 inhibits AR–mediated proliferation of breast cancer cells through the activation of SIRT1
Abstract
The Editors have retracted this Article. After publication, concerns were raised regarding similarities in the blots presented in the Figures, specifically: Fig. 1F MCF-7 and T47D GAPDH blots appear highly similar Fig. 2H MCF-7 GAPDH lanes 2-3 and MDA-MB-157 GAPDH lanes 1-2, respectively; Fig. 1F MCF-7 BRCA1 blot appears highly similar to Fig. 2C MAC-7 BRCA1 in [1]; Fig. 1F MCF-7 AR blot appears highly similar to MDA-MB-157 AR (with different exposure); Fig. 1F SK-BR-3 BRCA1 lane 2 appears highly similar to Fig. 3D SK-BR-1 mTOR lane 1; Fig. 2A T47D Skp2/b lane 2 appears highly similar to Fig. 2F MDA-MB-157 Skp2/b lane 2, flipped horizontally; Fig. 2A MDA-MB-157 Skp2/b lane 1 appears highly similar to Fig. 2F MDA-MB-157 Skp2/b lane 1, flipped horizontally; Fig. 2F T47D AR blot appears highly similar to Fig. 3F MDA-MB-157 SIRT1 lanes 2-3.
Fields of Study & Subjects
Estrogen and related hormone effects
BRCA gene mutations in cancer
Breast Cancer Treatment Studies
Publication details
- Journal / source
- Scientific Reports
- Volume
- 16
- Issue
- 1
- Pages
- 1750–1750
- Publication date
- 13 January 2026
- Language
- EN