Retraction Note: BRCA1 inhibits AR–mediated proliferation of breast cancer cells through the activation of SIRT1

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Authors: Wenwen Zhang, Jun Luo, Fang Yang, Yucai Wang, Y. Yin, Anders Ström, Jan Åke Gustafsson, Xiaoxiang Guan
Cited by: 0
References: 1

Abstract

The Editors have retracted this Article. After publication, concerns were raised regarding similarities in the blots presented in the Figures, specifically: Fig. 1F MCF-7 and T47D GAPDH blots appear highly similar Fig. 2H MCF-7 GAPDH lanes 2-3 and MDA-MB-157 GAPDH lanes 1-2, respectively; Fig. 1F MCF-7 BRCA1 blot appears highly similar to Fig. 2C MAC-7 BRCA1 in [1]; Fig. 1F MCF-7 AR blot appears highly similar to MDA-MB-157 AR (with different exposure); Fig. 1F SK-BR-3 BRCA1 lane 2 appears highly similar to Fig. 3D SK-BR-1 mTOR lane 1; Fig. 2A T47D Skp2/b lane 2 appears highly similar to Fig. 2F MDA-MB-157 Skp2/b lane 2, flipped horizontally; Fig. 2A MDA-MB-157 Skp2/b lane 1 appears highly similar to Fig. 2F MDA-MB-157 Skp2/b lane 1, flipped horizontally; Fig. 2F T47D AR blot appears highly similar to Fig. 3F MDA-MB-157 SIRT1 lanes 2-3.

Fields of Study & Subjects

Estrogen and related hormone effects BRCA gene mutations in cancer Breast Cancer Treatment Studies

Publication details

Journal / source
Scientific Reports
Volume
16
Issue
1
Pages
1750–1750
Publication date
13 January 2026
Language
EN