Copper catalyzed synthesis of thiazole derivatives from enaminones, amines and CS₂
Abstract
An efficient copper-catalyzed method for the synthesis of thiazoles from enaminones, amines, and carbon disulfide (CS₂) is described. This one-pot, ligand- and additive-free protocol proceeds under relatively simple reaction conditions, affording thiazole derivatives in good to excellent yields. Notably, CS₂ serves as a combined sulfur and carbon source, contributing to the synthetic practicality of the transformation. The method demonstrates good functional-group tolerance and provides a straightforward approach to biologically relevant thiazole scaffolds.
Fields of Study & Subjects
Sulfur-Based Synthesis Techniques
Catalytic C–H Functionalization Methods
Catalytic Cross-Coupling Reactions
Publication details
- Journal / source
- Scientific Reports
- Publisher
- Springer Science and Business Media LLC
- Volume
- 16
- Issue
- 1
- Publication date
- 16 February 2026
- Language
- EN