Junction opener enables CAR T cell treatment of solid tumors

Scientific Reports 2026 Open access

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Authors: Steven James Reed, Shibbu Sharma, Carrie Novák, Jiho Kim, Kaman Kim, Eréne C. Niemi, Nicholas A. Korjeff, André Lieber, Steven G. Reed, Malcolm S. Duthie, Darrick Carter
DOI: 10.1038/s41598-026-43093-8
Cited by: 0
References: 20

Abstract

Physical barriers presented by solid tumors limit CAR T cell efficacy. Thus, technologies to increase CAR T cell access to solid tumors could have massive implications in advancing CAR T cell therapies. Here we demonstrate that treatment of solid tumor-bearing mice with our Junction Opener technology and CAR T cells enhances tumor control - potentially enabling CAR T cell immunotherapy for solid tumors.

Fields of Study & Subjects

CAR-T cell therapy research Cancer Immunotherapy and Biomarkers Immunotherapy and Immune Responses

Publication details

Journal / source
Scientific Reports
Volume
16
Issue
1
Publication date
7 March 2026
Language
EN