Correction: Targeting cell surface GRP78-CD44v interaction suppresses cell migration in triple-negative breast cancer cells

The original version of this Article contained an error in Fig. 2, where the y-axis of the bar graph is partially cropped and not fully legible. The incorrect Figure 2 along with its captions is provided below. Fig. 2 MDA-MB-231 cells treated with the anti-GRP78 antibody (76-E6) exhibit an increased number of protrusions and reduced capacity for cell migration. ( a ) Confocal micrographs showing the F-actin structures of MDA-MB-231 cells treated with 76-E6 antibody or control IgG for 24 h. F-actin was visualized through rhodamine phalloidin staining or transfected mCherry-tagged actin binding peptide. Long open arrow, direction of cell migration. Short open arrows, membrane blebs. Short solid arrow, accumulation of disorganized F-actin. Scale bars, 20 μm. ( b ) Bright-field micrographs showing the morphology of MDA-MB-231 cells treated with 76-E6 antibody for 49 h. Solid arrows, short cell protrusions. Open arrows, long cell protrusions. Arrowheads, primary (1), secondary (2), and tertiary (3) cell protrusions. Scale bar, 100 μm. ( c ) The percentage of cells displaying the indicated number of long cell protrusions after treatment with 76-E6 or control IgG for 61 h. Total number of cells analyzed in the study: 2699 (IgG); 942 (76-E6). ( d ) Upper: Superimposed tracks of control IgG ( n = 32) and 76-E6 antibody ( n = 28)-treated MDA-MB-231 cells during a 7-h random migration assay. Lower: Comparisons of velocity (displacement/time) and straightness (displacement/total path length) of the cells. The unpaired two-tailed Student’s t-test was used to calculate the p -values; error bars represent the standard deviation (SD). The raw statistical data are provided in Supplementary Information 1. ( e ) Time-lapse DIC images of MDA-MB-231 cells during a 2-h observation period. Solid lines, cell borders. Dotted lines, positions of the cells. min, minutes. Full size image