pH profiling reveals progressive wound acidification during healing and higher pH in chronic non-healing wounds: a prospective, multicenter cohort study

Scientific Reports 2026 Open access

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Authors: Julian‐Dario Rembe, Mareike Witte, Neslihan Ertas, Joachim Dissemond, Waseem Garabet, MARIA HOVHANNISYAN, Katharina Beckamp, Hubert Schelzig, Markus U. Wagenhäuser, Ewa K. Stuermer
DOI: 10.1038/s41598-026-45000-7
Cited by: 9
References: 28

Abstract

The local microenvironment of wounds plays a crucial role in healing, with pH and temperature emerging as promising biomarkers. This prospective, multi-center, observational study assessed pH and temperature in acute and chronic wounds to identify physicochemical patterns associated with healing. A total of 117 patients with various wound etiologies underwent 226 pH and 181 temperature measurements at the wound center, edge, and surrounding skin. With a pH of 7.113 ± 0.659 and 7.043 ± 0.694, chronic and non-healing wounds exhibited significantly higher pH values than acute (6.592 ± 0.617) and healing wounds (6.820 ± 0.814; p

Fields of Study & Subjects

Wound Healing and Treatments Helicobacter pylori-related gastroenterology studies Pressure Ulcer Prevention and Management

Publication details

Journal / source
Scientific Reports
Publisher
Springer Science and Business Media LLC
Volume
16
Issue
1
Publication date
27 March 2026
Language
EN