NLRP3 inflammasome characterization in first-trimester, preterm, and term human villous placenta

Scientific Reports 2026 Open access

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Authors: Fiona Kumnova, Matylda Gradzka, Mohammed Ali, Cilia Abad, Ніна Вебер, Lukáš Červený, Jaroslav Stráník, Tomáš Faist, Marián Kacerovský, František Štaud, Rona Karahoda
DOI: 10.1038/s41598-026-58051-7
Cited by: 1
References: 68

Abstract

Precise regulation of inflammatory signaling at the maternal-fetal interface is essential for a healthy pregnancy, yet how the NLRP3 inflammasome is regulated in the placenta during pregnancy and in preterm birth remains poorly understood. We characterized NLRP3 inflammasome-associated signaling in human villous placental tissue from first-trimester (8-11 weeks), preterm (28-

Fields of Study & Subjects

Preterm Birth and Chorioamnionitis Pregnancy and preeclampsia studies Reproductive System and Pregnancy

Publication details

Journal / source
Scientific Reports
Publisher
Springer Science and Business Media LLC
Volume
16
Issue
1
Publication date
20 June 2026
Language
EN