OnCorr: A pan-cancer mRNA-protein correlation tool for precision oncology

npj Precision Oncology 2026 Open access

Read full text
Authors: Urwah Nawaz, Niantao Deng, Ori Livson, Chelsea Mayoh, Loretta M. S. Lau, Roger R. Reddel, Bhavna D. Padhye, Rebecca C. Poulos
DOI: 10.1038/s41698-026-01323-2
Cited by: 1
References: 29

Abstract

Proteins are ultimately responsible for cellular phenotypes and are targeted by most anticancer drugs. However, beyond immunohistochemistry, proteins are not typically measured in precision oncology, meaning transcriptomics is used as a proxy. To determine how informative mRNA is for guiding personalised treatments, mRNA-protein correlations were analysed in three large pan-cancer datasets and made available in a web portal ( https://oncorr.aws.procan.org.au/ ). OnCorr can be integrated into precision medicine programs to augment transcriptomics.

Fields of Study & Subjects

Single-cell and spatial transcriptomics Ferroptosis and cancer prognosis Bioinformatics and Genomic Networks

Publication details

Journal / source
npj Precision Oncology
Publisher
Springer Science and Business Media LLC
Volume
10
Issue
1
Publication date
12 February 2026
Language
EN