Real-world multicenter assessment of sustained clinical outcomes after digital deep brain stimulation

npj Digital Medicine 2026 Open access

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Authors: A Gharabaghi, Sergiu Groppa, Elena Casas, Prof Alfons Schnitzler, Laura Muñoz-Delgado, Vicky L. Marshall, Jessica Karl, Lin Zhang, Ramiro Álvarez, Mary Feldman, Michael J. Soileau, Lan Luo
+8 more Benjamin L. Walter, Chengyuan Wu, Hong Gang Lei, Damian M. Herz, Devyani Nanduri, Claudia Salazar, Corneliu Luca, Daniel Weiß
DOI: 10.1038/s41746-025-02315-5
Cited by: 3
References: 18

Abstract

Remote, internet-based deep brain stimulation programming for Parkinson's disease accelerates clinical benefits postoperatively by improving access to therapy adjustments compared to in-clinic optimization. After completion of the initial digital programming phase, we show that clinical outcomes, quality of life, and safety remain sustained over at least twelve months under routine care conditions. Embedding a randomized trial within a larger cohort study enables long-term, real-world evaluation, offering a scalable and pragmatic model for assessing complex digital interventions in routine clinical care. (NCT05269862 registered on 2022-03-08 and NCT04071847 registered on 2019-08-28).

Fields of Study & Subjects

Neurological disorders and treatments Digital Mental Health Interventions Vagus Nerve Stimulation Research

Publication details

Journal / source
npj Digital Medicine
Publisher
Springer Science and Business Media LLC
Volume
9
Issue
1
Pages
133–133
Publication date
14 January 2026
Language
EN