Unlocking Lewis acid–free metalation of O–nucleophiles in HFIP
Abstract
Allylsilanes are primarily used in allylation reactions that form new C-C bonds. Although they can also serve as silylating reagents to generate Si-O bonds, such transformations have generally required Brønsted or Lewis acid catalysis. Herein, we describe an acid-free method to access silyl ethers, siloxanes, and borasiloxanes via silylation or borylation. Hexafluoroisopropanol enables this reactivity, allowing a wide range of alcohols and silanols to undergo efficient conversion under mild conditions.
Fields of Study & Subjects
Coordination Chemistry and Organometallics
Organoboron and organosilicon chemistry
Catalytic Cross-Coupling Reactions
Publication details
- Journal / source
- Communications Chemistry
- Publisher
- Springer Science and Business Media LLC
- Volume
- 9
- Issue
- 1
- Publication date
- 2 June 2026
- Language
- EN