Modelling drug-induced cellular perturbation responses with a biologically informed dual-branch transformer

Nature Machine Intelligence 2026 Open access

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Authors: Yue Guo, Hao Zhang, Haitao Hu, Jialu Wu, Ji Cao, Chang-Yu Hsieh, Bo Yang
DOI: 10.1038/s42256-025-01165-w
Cited by: 13
References: 49

Abstract

A dual-branch framework that disentangles cell states from drug-induced regulatory shifts to predict transcriptional responses is presented. It captures nonlinear dose–time dynamics and excels in generalizing to unseen cellular contexts.

Fields of Study & Subjects

Gene Regulatory Network Analysis Molecular Communication and Nanonetworks Slime Mold and Myxomycetes Research

Publication details

Journal / source
Nature Machine Intelligence
Publisher
Springer Science and Business Media LLC
Volume
8
Issue
1
Pages
96–112
Publication date
26 January 2026
Language
EN