The MEK–RAF molecular glue IK-595 has potent antitumor activity across RAS/MAPK pathway-altered cancers

Nature Cancer 2026

View at publisher
Authors: Eric Haines, Michael Burke, Rachel Catterall, Víctor R. De Jesús, Daniel Hidalgo, Bin Li, Joseph Manna, Ao Yang, Jill Cavanaugh, Sarah R. Wessell, Marta Sanchez-Martin, Alexander E. Ivliev
+5 more Wilmin Bartolini, Sergio Santillana, Jeffrey Ecsedy, Michelle Zhang, Sabine K. Ruppel
DOI: 10.1038/s43018-025-01081-3
Cited by: 4
References: 37

Fields of Study & Subjects

Melanoma and MAPK Pathways NF-κB Signaling Pathways Protein Degradation and Inhibitors

Publication details

Journal / source
Nature Cancer
Publisher
Springer Science and Business Media LLC
Volume
7
Issue
1
Pages
116–130
Publication date
2 January 2026
Language
EN