Temporal and spatial composition of the tumor microenvironment predicts response to immune checkpoint inhibition in metastatic TNBC

Nature Cancer 2026 Open access

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Authors: Noah F. Greenwald, Iris Nederlof, C. H. Sowers, Daisy Yi Ding, Seongyeol Park, Alex Kong, Kathleen E. Houlahan, Sricharan Reddy Varra, Manon de Graaf, Veerle Geurts, Candace C. Liu, Jolene S. Ranek
+26 more Leonie Voorwerk, Michiel de Maaker, Adam Kagel, Erin McCaffrey, Aziz Khan, Christine Y. Yeh, Christine Camacho Fullaway, Zumana Khair, Brennan Simon, Yunhao Bai, Hadeesha Piyadasa, Tyler Risom, Alea Delmastro, Felix J. Hartmann, Lise Mangiante, Cristina Sotomayor-Vivas, Sean C. Bendall, Ton N. Schumacher, Zhicheng Ma, Marc Bossé, Marc J. van de Vijver, Robert Tibshirani, Hugo M. Horlings, Christina N. Curtis, Marleen Kok, Michael Angelo
DOI: 10.1038/s43018-026-01114-5
Cited by: 7
References: 86

Fields of Study & Subjects

Cancer Immunotherapy and Biomarkers Single-cell and spatial transcriptomics Ferroptosis and cancer prognosis

Publication details

Journal / source
Nature Cancer
Publisher
Springer Science and Business Media LLC
Volume
7
Issue
3
Pages
435–450
Publication date
18 February 2026
Language
EN