Inhibition of ADSS2-mediated de novo AMP biosynthesis re-sensitizes acute myeloid leukemia to BH3 mimetics

Nature Cancer 2026

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Authors: Xin He, Lei Zhang, Y Li, Songbai Liu, Zheng Li, Haojie Dong, Genevieve E. Baker, Le Xuan Truong Nguyen, Wei Chen, Jinhui Wang, Zhilian Jia, Xiyuan Lu
+21 more Yi‐Chun Lin, Zunsong Hu, Umesh Prasad Yadav, Meng Liu, Leying Zhang, Zhenhua Chen, Xiwei Wu, Jianjun Chen, Chun-Wei David Chen, Stefano Tiziani, Weidong Hu, Ya‐Huei Kuo, Shengli Xue, Yong Zhang, Min Li, Yaoqiu Zhu, Guido Marcucci, Zhaohui Gu, J. Jefferson P. Perry, Yun Luo, Ling Li
DOI: 10.1038/s43018-026-01184-5
Cited by: 1
References: 63

Fields of Study & Subjects

Biochemical and Molecular Research Folate and B Vitamins Research Adenosine and Purinergic Signaling

Publication details

Journal / source
Nature Cancer
Publisher
Springer Science and Business Media LLC
Volume
7
Issue
6
Pages
944–963
Publication date
26 June 2026
Language
EN