Metformin inhibits nuclear egress of chromatin fragments in senescence and aging

Nature Aging 2026

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Authors: Takuya Kumazawa, Yi Xu, Yu Wang, Ji-Won Lee, Tara C. O’Brien, Chia-Kang Ho, Murat Çetinbaş, Aaron I. Weiner, Konrad Hochedlinger, Ruslan I. Sadreyev, Nabeel Bardeesy, Chia-Wei Cheng
+2 more Bin He, Zhixun Dou
DOI: 10.1038/s43587-025-01048-0
Cited by: 7
References: 58

Fields of Study & Subjects

interferon and immune responses Nuclear Structure and Function Chromatin Remodeling and Cancer

Publication details

Journal / source
Nature Aging
Publisher
Springer Science and Business Media LLC
Volume
6
Issue
2
Pages
303–315
Publication date
16 January 2026
Language
EN