Exercise alleviates cognitive dysfunction in Alzheimer’s disease mice via skeletal muscle-derived extracellular vesicles that enhance plaque clearance by microglia

Nature Aging 2026

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Authors: Jiaquan Lin, Xiaoyan Shao, Tianshu Shi, Haosheng Wang, Pan Zhang, Yining Zhou, Liu Na, Yi He, Depeng Fang, Yong Shi, Yuze Ma, Bin Liu
+12 more Wang Gong, Wenshu Wu, Rui Peng, Chengzhi Wang, Tao Shen, Zhuoying Jiang, Yu Ben, Jianghui Qin, Zhihong Xu, Xiang Chen, Qing Jiang, Guo Baosheng
DOI: 10.1038/s43587-026-01075-5
Cited by: 14
References: 88

Fields of Study & Subjects

Extracellular vesicles in disease Neuroinflammation and Neurodegeneration Mechanisms Alzheimer's disease research and treatments

Publication details

Journal / source
Nature Aging
Publisher
Springer Science and Business Media LLC
Volume
6
Issue
3
Pages
579–596
Publication date
2 March 2026
Language
EN