Single-nucleus interrogation of primate small intestinal aging reveals NCoR1 decline as a conserved feature that is reversed by metformin

Nature Aging 2026

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Authors: Jingyi Li, Xiaoyong Lu, Tianhong Tong, X Zhou, Baohu Zhang, Xiaoyan Sun, Bing Zhao, Gang Xu, Jie Yang, Yanling Fan, Jianli Hu, Haoteng Yan
+13 more Zhejun Ji, Mingheng Li, Shanshan Che, Yuanhan Yang, Yingjie Ding, Qiaoran Wang, Shuhui Sun, Shuai Ma, Si Wang, J C Izpisua Belmonte, Jing Qu, Weiqi Zhang, Guang-Hui Liu
DOI: 10.1038/s43587-026-01131-0
Cited by: 3
References: 111

Fields of Study & Subjects

Metabolism Diabetes and Cancer Cancer Cells and Metastasis Epigenetics and DNA Methylation

Publication details

Journal / source
Nature Aging
Publisher
Springer Science and Business Media LLC
Volume
6
Issue
6
Pages
1298–1318
Publication date
9 June 2026
Language
EN