Emerging biomarkers and diagnostic tools for the early prediction of adverse prenatal outcomes

npj Women s Health 2026 Open access

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Authors: Marc Soler, Brenna Parke, Sung Youn Kim, Vasso Terzidou, Sylvain Ladame
DOI: 10.1038/s44294-026-00138-7
Cited by: 1
References: 127

Abstract

Abstract Clinical interventions for adverse pregnancy outcomes (APOs, 1 in 5 pregnancies) are most effective when administered early ( < 16–28 weeks), however risk-stratification in this window remains challenging. Here we review the main classes of biomarkers (proteins, nucleic acids, bacteria and biometabolites) showing high and early predictive value for the most prevalent APOs (preeclampsia, preterm birth, small for gestational age), and recent technological advances to develop non-invasive prenatal tests for these APOs.

Fields of Study & Subjects

Pregnancy and preeclampsia studies Preterm Birth and Chorioamnionitis Reproductive System and Pregnancy

Publication details

Journal / source
npj Women s Health
Publisher
Springer Science and Business Media LLC
Volume
4
Issue
1
Publication date
21 April 2026
Language
EN