Visualising viral interactions and mechanisms at the nanoscale with expansion microscopy

npj Viruses 2026 Open access

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Authors: Lisa Övermöhle, Maximilian Baum, Rohan Bhatia, Karin Byskata, Katharina M. Scherer
DOI: 10.1038/s44298-025-00169-y
Cited by: 3
References: 96

Abstract

Expansion microscopy is a groundbreaking technique that enables nanoscale imaging of biological specimens using standard optical microscopes. By embedding specimens in swellable hydrogels, it achieves sub-diffraction resolution. Compatible with various tissue types, it offers 3D, multi-colour visualisation of cellular and sub-cellular structures. While challenges remain, like sample isotropy and preservation of molecular integrity, expansion microscopy is a transformative tool for cell and neurobiology. Here, we discuss its potential for virology.

Fields of Study & Subjects

Advanced Fluorescence Microscopy Techniques Nanofabrication and Lithography Techniques Near-Field Optical Microscopy

Publication details

Journal / source
npj Viruses
Publisher
Springer Science and Business Media LLC
Volume
4
Issue
1
Pages
1–1
Publication date
6 January 2026
Language
EN