Mitotic entry: Bora takes Polo to Aurora, and gives them a hug
Abstract
Cell division involves the complete reorganization of the cellular architecture, requiring precise coordination of cellular processes in space and time, but how does this control system work at the atomic level? Three new studies offer a glimpse under the hood, revealing structural details of the intricate interactions between Aurora A and PLK1 kinases and the co-factor Bora, and how they act together to trigger timely entry to mitosis. Three new studies reveal structural details of the intricate interactions between Aurora A and PLK1 kinases and the co-factor Bora, and how they act together to trigger timely entry to mitosis.
Fields of Study & Subjects
Microtubule and mitosis dynamics
Nuclear Structure and Function
Axon Guidance and Neuronal Signaling
Publication details
- Journal / source
- The EMBO Journal
- Publisher
- Springer Science and Business Media LLC
- Volume
- 45
- Issue
- 5
- Pages
- 1423–1425
- Publication date
- 28 January 2026
- Language
- EN