The Goldilocks paradox: when partial oncoprotein inhibition fuels metastasis in Ewing sarcoma

EMBO Molecular Medicine 2026 Open access

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Authors: Marie Castets, Adrien Bertrand‐Chapel, Jean-Yves Blay
DOI: 10.1038/s44321-025-00365-6
Cited by: 0
References: 6

Abstract

Targeting oncogenic fusion proteins remains a major challenge in pediatric oncology. In this issue of EMBO Molecular Medicine, Suresh et al (2025) demonstrate that incomplete inhibition of EWS::FLI1 in Ewing sarcoma paradoxically promotes metastatic behavior, revealing critical implications for therapeutic strategies. JY Blay & colleagues discuss the study by Suresh et al, in this issue of EMBO Mol Med, that shows that incomplete inhibition of EWS::FLI1 in Ewing sarcoma paradoxically promotes metastatic behavior.

Fields of Study & Subjects

Sarcoma Diagnosis and Treatment Cardiomyopathy and Myosin Studies Protein Degradation and Inhibitors

Publication details

Journal / source
EMBO Molecular Medicine
Publisher
Springer Science and Business Media LLC
Volume
18
Issue
2
Pages
360–361
Publication date
3 January 2026
Language
EN