5-ALA does not potentiate dihydroartemisinin against Plasmodium falciparum malaria parasites
Abstract
In this Correspondence, H. Behrens and colleagues show that the potentiating effect of the small molecule 5-aminolaevulinic acid (5-ALA) on the activity of artemisinin observed in cancer does not translate to malaria parasites. Thus, co-administration of artemisinin and 5-ALA does not seem to be a promising strategy to improve malaria treatment.
Fields of Study & Subjects
Malaria Research and Control
Biological Research and Disease Studies
Pharmacological Effects of Natural Compounds
Publication details
- Journal / source
- EMBO Molecular Medicine
- Publisher
- Springer Science and Business Media LLC
- Volume
- 18
- Issue
- 4
- Pages
- 1130–1133
- Publication date
- 27 February 2026
- Language
- EN