CCorGsDB: a database for clock correlated genes in the mouse and human central nervous systems

npj Biological Timing and Sleep 2026 Open access

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Authors: José Luiz Araújo Santos, Vinícius Tenório Braga Cavalcante Pinto, Thales Eduardo da Silva Santos, Daniel Gomes Coimbra, Tiago Gomes de Andrade
DOI: 10.1038/s44323-025-00064-y
Cited by: 1
References: 54

Abstract

We developed CCorGsDB, a web-based resource integrating mouse and human CNS co-expression networks filtered by circadian biomarkers. We validated the networks using time-series data from sixteen mouse regions and identified a conserved set of 251 orthologs enriched for RNA processing, chromatin regulation, and autism-related phenotypes. The database links CCorGs to disease terms and short-half-life CNS-active drugs with spatially resolved profiles. CCorGsDB is available at https://famed.ufal.br/ccorgs .

Fields of Study & Subjects

Circadian rhythm and melatonin Bioinformatics and Genomic Networks Single-cell and spatial transcriptomics

Publication details

Journal / source
npj Biological Timing and Sleep
Publisher
Springer Science and Business Media LLC
Volume
3
Issue
1
Publication date
9 January 2026
Language
EN