Parkin–ACSL4 axis in ferroptosis regulation: a narrative review on therapeutic insights from exercise in aging cardiomyocytes
Abstract
Ferroptosis, iron-dependent regulated cell death, drives age-related cardiac dysfunction. This review examines aerobic exercise modulation of ferroptosis in aging cardiomyocytes via Parkin-ACSL4 axis. Parkin promotes ACSL4 ubiquitination/degradation, reducing lipid peroxidation and ROS. Exercise activates PINK1/Parkin mitophagy and hepcidin, enhancing mitochondrial resilience and iron homeostasis. Despite promising preclinical evidence, molecular mechanisms remain unclear. Aerobic exercise offers non-pharmacological cardiac protection against ferroptosis in aging.
Fields of Study & Subjects
Ferroptosis and cancer prognosis
Autophagy in Disease and Therapy
Cardiovascular Health and Risk Factors
Publication details
- Journal / source
- npj Metabolic Health and Disease
- Publisher
- Springer Science and Business Media LLC
- Volume
- 4
- Issue
- 1
- Pages
- 1–1
- Publication date
- 6 January 2026
- Language
- EN