Hallmarks of nuclear metabolism: implications for genome integrity, nuclear signaling, and therapeutic targeting
Abstract
Certain metabolic enzymes localize to the nucleus, where they perform regulatory functions that extend far beyond canonical metabolism. Once inside, they influence chromatin organization, transcription, DNA repair, and cell cycle progression. This review summarizes recent advances that redefine metabolism as a nuclear process and reshape our understanding of metabolic regulation. It further defines the emerging hallmarks of nuclear metabolism and discusses how these insights open new avenues for cancer therapies.
Fields of Study & Subjects
Nuclear Structure and Function
Cancer
Hypoxia
and Metabolism
Retinoids in leukemia and cellular processes
Publication details
- Journal / source
- npj Metabolic Health and Disease
- Publisher
- Springer Science and Business Media LLC
- Volume
- 4
- Issue
- 1
- Pages
- 6–6
- Publication date
- 2 February 2026
- Language
- EN